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Diseases of the urinary system are among the most common in modern society. In their treatment, various diuretics are taken, which significantly affect the work of the kidneys, which are already at risk for this kind of disease. Studying the effect of diseases of the urethra on this organ is critical for medical specialists. Moreover, it is necessary to have a clear understanding of how diuretics, which are prescribed for other diseases of the body, act on the functioning of the nephron.
One of the most well-known diuretics that are prescribed to patients is Thalitone or Chlorthalidone. This drug is prescribed for the treatment of high blood pressure. The primary mechanism of its action is to accelerate the work of the renal system and promotes the excretion of fluid from the body (Le, 2022). It is claimed that Thalitone is one of the safest in the treatment of blood pressure-related diseases; however, it has several severe consequences for both the nephron and the entire body. Among them may be such as the occurrence of low potassium, which is reflected in muscle weakness, cramping, and fatigue (Le, 2022). This aspect directly affects the functioning of such a part of the nephron as the glomerulus.
It is worth noting that in addition to low potassium, Thalitone may have other side effects that require attention. Thus, increased urination may become a problem for many patients. Despite the fact that this is a direct effect of a diuretic, it can cause discomfort for individuals and interfere with a normal lifestyle. Regarding nephrons, this drug also causes low levels of electrolytes such as sodium, magnesium, and calcium (Le, 2022). To prevent these undesirable consequences, patients are often prescribed electrolyte supplements.
Another essential aspect that needs to be considered is how diseases of the urethra affect the functioning of the renal system. Tuberculosis of the genitourinary system becomes one of the deviations of the body’s work, which has a rather severe effect on the nephron. Despite the fact that this disease is not characterized by high prevalence, it has a detrimental effect on the kidneys. Hence, it can lead to kidney destruction, which occurs as a result of hematogenous dissemination.
Tuberculosis of the genitourinary system thus directly affects not only the functioning of the patient’s renal system but also the organ itself. During the disease, it may show bumps in the cortical layer of the parenchyma (Muneer et al., 2019). With particularly serious infections or lack of treatment, caseous necrosis occurs at the site of the lesion. The main danger of this process is that it can affect the surrounding tissues and cause even more harmful consequences for the organ. The consequence is the previously mentioned violation of the functioning of the renal system, which in turn can cause subsequent diseases.
In conclusion, the kidneys are one of the most essential organs of the human body; however, they carry a heavy load. This is due to the fact that drugs such as Thalitone directly. They affect their work and can cause abnormalities in electrolytes. On the other hand, diseases of the urethra, such as tuberculosis of the genitourinary system, can cause disorders not only of kidney function but also of their structure. The bumps on the nephron caused by the deviation can turn into nectar and affect the surrounding tissues of the organ.
References
Le, K. (2022). 8 chlorthalidone side effects you should know about. GoodRx Health. Web.
Muneer, A., Macrae, B., Krishnamoorthy, S., & Zumla, A. (2019). Urogenital tuberculosis-epidemiology, pathogenesis and clinical features. Nature Reviews Urology, 16(10), 573-598. Web.
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