Selective Serotonin Reuptake Inhibitors and Risk of Suicide

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Table of Contents

Introduction
Methods
Main Results and Implications
Conclusion
Reference

Introduction

The article under analysis is a systematic review by Barbui, Esposito, and Cipriani (2009) who aimed to explore the relationship between selective serotonin reuptake inhibitors (SSRIs) and suicide risks. The topic is highly relevant as antidepressants are widely used to treat anxiety disorders and a range of other psychological conditions. In this paper, the methods, main results, and implications will be reviewed.

Methods

The researchers undertook a meta-analysis of eight articles with a combined sample of 200,000 people diagnosed with a mild or severe case of depression and treated with SSRIs. Data collection was conducted in accordance with the quality of reporting of meta-analysis (Barbui et al., 2009). MEDLINE and EMBASE databases for medical research were used as sources of articles dated between 1990 and 2008. The methods appear to be characteristic of fine quality research as only approved study methods, reliable sources, and frameworks were used.

Main Results and Implications

The authors found that SSRI exposure was positively related to suicide risk in adolescents, in adults the risk was, on the contrary, decreased. In older adults, antidepressants were similarly effective against depression symptoms. The results were tested as per sensitivity, yet no changes were registered which adds to the validity of the findings (Barbui et al., 2009). Such discovery suggests that young people are at a more significant risk of SSRI side effects than other populations. The results imply that the use and prescription of antidepressants in adolescents needs to be reviewed by boards of medical professionals. In addition, the possibility of SSRI limitation or prohibition needs to be considered. Researchers suggest that prior to such actions, additional studies need to be conducted in this vulnerable group.

Conclusion

The article contributed to broadening the knowledge in the sphere of SSRI use and effects. The researchers identified the increased suicide risks in adolescents who consume antidepressants. On the other hand, the opposite effect was found in adults and older adults. The main implication is that the use of SSRI to counter depression in younger populations need to be reassessed.

Reference

Barbui, C., Esposito, E., & Cipriani, A. (2009). Selective serotonin reuptake inhibitors and risk of suicide: A systematic review of observational studies. Canadian Medical Association, 180(3), 291-297. Web.

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Selective Serotonin Reuptake Inhibitors and Risk of Suicide

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