The Contribution of Epidemiology to Understanding Cardiovascular Diseases

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Table of Contents

Introduction
Epidemiology
Cardiovascular Diseases
Epidemiological Approaches
Discussion and Analysis of the Reports
Discussion and Analysis of Policy Initiatives
Critique of Epidemiological Research Studies on CVD
Conclusion
Reference List

Introduction

The subject of cardiovascular disease (CVD) will serve as the focus of this particular assignment. Cardiovascular disease is used to describe a group of conditions that negatively impact the cardiovascular system. This system includes the heart and the arteries, veins, and capillaries. The field of epidemiology has made substantial advances in the awareness of cardiovascular disease (CVD), which is among the main causes of death around the globe. Epidemiologists have assisted in enlightening the intricate dynamic between environmental exposures and lifestyle aspects that influence the course of CVD by analyzing disease prevalence trends and specifying the risk factors linked to cardiovascular disease. The aim of this task is to conduct an in-depth analysis of the input that epidemiology makes to the comprehension of cardiovascular diseases as well as the policy response to these conditions. This will comprise defining epidemiology, characterizing cardiovascular diseases (CVD), addressing various epidemiological methodologies, examining epidemiological findings and policy approaches, and giving criticisms where necessary.

Epidemiology

Epidemiology is the scientific study of the factors that contribute to health and illness in a population, as well as the prevalence and dispersion of these factors. It is a descriptive field that involves determining rates, such as estimating the frequency of sickness in a certain group (Centers for Disease Control and Prevention, 2023). In order to correctly evaluate the epidemiological data relevant to an illness, it is necessary to know the diseases history and current occurrence. Epidemiology is a scientific discipline concerned with the analysis of data gathered through surveys and other methods to draw conclusions about the health of communities, regions, and even whole organizations. One of the goals of epidemiologic research is to explain the features of a disease, such as the associated risk factors, and to design the most efficient techniques for disease control. Furthermore, epidemiology seeks to assess the efficacy of various approaches to disease prevention, management, and control by pinpointing potential cause elements in the etiology of a given illness.

Cardiovascular Diseases

Cardiovascular diseases (CVDs) include, among others, coronary heart disease, stroke, peripheral arterial disease, and deep vein thrombosis. Instances of cardiovascular disease include at least one of the following conditions: coronary artery disease, atrial fibrillation (AF), stroke, hypertension, transient ischemic attack, and congestive heart failure (Hinton et al., 2018). Assessing the risk of cardiovascular disease is essential for identifying preventative measures. Defining and monitoring the evolution of risk factors for CVD are the fundamental stages in assessing heart disease risk. The most significant behavioral factors associated with cardiovascular disease and stroke include a poor diet, physical inactivity, cigarette use, and excessive alcohol use (World Health Organization, 2021). The impacts of behavioral risk factors may manifest as elevated blood pressure, blood glucose, blood lipids, and obesity in people. Stroke, sudden cardiac arrest, and other outcomes may be predicted based on these risks, which can be evaluated in primary care facilities.

The underlying illness of the blood vessels often does not present symptoms in its early stages. A stroke or heart attack may have been the initial indicator of anything more serious. Pain or discomfort in the center of the chest, as well as discomfort or pain in the arms, are symptoms that might indicate a potential heart attack. Furthermore, the person may have breathlessness, dizziness, light-headedness, chilly sweat, and pallor. It is more common for women than males to experience shortness of breath, nausea or vomiting, and pain in the back or jaw (World Health Organization, 2021). Consequently, it is very important for those exhibiting these symptoms to get medical attention as soon as possible.

The key to reducing cardiovascular disease is to include cardiovascular disease management therapies in proposals for universal health care. Worldwide, cardiovascular illnesses are the major cause of mortality (Deng, Leng, and Nie, 2022). In 2019, an approximated 17,9 million individuals died from CVDs, accounting for 32% of all fatalities worldwide. Eighty-five percent of these fatalities were attributable to stroke or heart attack (Deng, Leng, and Nie, 2022). Hinton et al. (2018) found that the prevalence and frequency of diseases rose with age. CVD was observed in fewer than 1 percent of adults younger than 50, 25 percent of those with at least one disease between the ages of 70-79, and over 40 percent of individuals over 80 (Hinton et al., 2018). In research by Al-Shamsi, Regmi, and Govender (2019), the incidence rate of serious CVD was 12.7 in every 1000 person-years, with rates of 16.8 and 9.0 per 1000 person-years for men and women, respectively. This research revealed that severe cardiovascular diseases are substantially more prevalent in males than in women.

Epidemiological Approaches

Nutritional Epidemiology

The field of nutritional epidemiology has significantly improved knowledge of the intricate connection between food and cardiovascular health. Unhealthy dietary habits such as excessive intake of salt and processed foods, lower consumption of vegetables, fruits, unhealthy fats, fiber, and legumes, along with a lack of exercise, obesity, stress, alcohol intake, or cigarette smoking, are associated with an increased risk of cardiovascular disease (Casas et al., 2018). According to a significant amount of scientific research, diet may be the most important factor in preventing mortality from CVD and might potentially cure cardiovascular diseases (Casas et al., 2018). Effective control of these lifestyle factors would benefit vulnerable groups. By 2030, it is anticipated that 43.9 percent of the US elderly population will have some CVD (Yin et al., 2022). Seventy-five percent of pre-mature Cardiovascular events are avoidable by early intervention, according to epidemiological research (Yin et al., 2022). A complete knowledge of the etiology and underlying processes of cardiovascular disease remains a top objective.

Social Epidemiology

Social determinants of health (SDoH), which include socioeconomic, environmental, and psychological variables that impact health, have a crucial impact on the advancement of CVD risk factors and CVD mortality and morbidity. These areas may be causes of chronic psychosocial stresses for people with low socioeconomic status, restricted access to healthcare, insecure housing, early childhood trauma, prejudice, food insecurity, and poor sleep quality, among others. Biologic consequences of adversity enhance the development of chronic inflammation (Powell-Wiley et al., 2022). These inflammatory mechanisms increase CVD risk factors, including obesity, high blood pressure, and atherosclerosis, which eventually contribute to major cardiovascular events and CVD mortality (Powell-Wiley et al., 2022). Furthermore, it is well-researched that psychosocial variables, or traits that influence persons mentally or socially, are highly related to cardiovascular health consequences (Powell-Wiley et al., 2022). Poor social ties were related to a 29 percent rise in the risk of heart disease and a 33% rise in the likelihood of stroke, according to a new meta-analysis of longitudinal studies (Bu, Zaninotto, and Fancourt, 2020). Nevertheless, there is limited evidence that social and solitary isolation are cardiovascular disease risk factors.

Discussion and Analysis of the Reports

In recent decades, research on CVD risk factors has been conducted; they have demonstrated that age, smoking, overweight, cholesterol levels, poor food patterns, level of education, hypertension, and diabetes all influence risk. Clinical trials and observational studies have explored the possible impact of antioxidant micronutrients and their safe dosage in preventing or treating cardiovascular disease (Yin et al., 2022). Epidemiology studies of specific micronutrients found that vitamin A, vitamin C, vitamin E, carotenoids, zinc, iron, and copper in the diet were related to decreased cardiovascular disease risk and cardiovascular death (Yin et al., 2022). These connections were considerably more obvious in the deficiency stage of subsequent micronutrients, and serum concentrations are directly connected to the number of dietary metal micronutrients.

The efficacy of antioxidant micronutrients, either separately or in conjunction with the treatment or mitigation of cardiovascular disease, is debatable. This was confirmed in a cross-sectional study by Yin et al. (2022), where supplementation with the antioxidant vitamins C and E had no impact on the incidence of cardiac events, stroke, and cardiac-related fatalities, according to analyses of 15 clinical studies with 188,209 individuals. Some studies have also claimed that antioxidant supplementation may raise the risk of cardiovascular disease due to possible peroxidation (Yin et al., 2022). Regarding dose, length of therapy, and baseline micronutrient condition of people receiving treatments, research on the benefits of dietary antioxidants faces several obstacles; in particular, the interacting impacts between micronutrients cannot be neglected (Yin et al., 2022). There is a fast-developing concern in the health consequences of dietary exposure to mixtures of nutritional antioxidant micronutrients since mixed exposure more accurately reflects the diverse diets individuals consume in real life.

The field of social epidemiology, which focuses on the social factors that might affect an individuals health, has given insight into the disproportionate effect that SDoH has on disadvantaged communities. In the past, there has been a rise in concern over the psychological and behavioral risks that are associated with loneliness as well as social alienation as a risk factor. Prior research has highlighted loneliness and social seclusion as risk variables for all-cause and cardiovascular disease-specific death. Longitudinal research examining cardiovascular disease (CVD) in a broader context discovered that living alone was connected with an increased risk of CVD (Bu, Zaninotto, and Fancourt, 2020). Nonetheless, another research revealed that loneliness, but not social isolation, was independently related to a 27 percent increase in the risk of cardiovascular disease (Bu, Zaninotto, and Fancourt, 2020). There is a shortage of studies examining CVD beyond chronic heart disease and stroke, and it remains unclear if loneliness and social alienation have a comparable association with CVD.

Discussion and Analysis of Policy Initiatives

Epidemiological findings have significantly shaped policy approaches to CVD. A variety of programs have been put in place by policymakers to prevent and manage CVD focused on epidemiological studies. For instance, programs to lower smoking rates, encourage healthy eating, increase physical activity, and manage high blood pressure have been implemented in numerous nations. This collection of research identifies methods for community-based treatments that seek to lessen CVD disparities. For instance, an evaluation of three-year salt reduction strategies in three community meal services in Arkansas was conducted by Long et al. (2021). By customizing community-level techniques depending on a communitys available assets, stage of preparedness, and degree of involvement with the food service employees, Jordan et al. (2020) showed the varying benefits of salt reduction approaches in food service contexts. These studies demonstrate the value and long-term sustainability of implementing salt reduction programs to lower CVD in areas with high rates of hypertension, food shortages, and low incomes. The results show that community-based approaches are efficient in raising awareness of CVD-related risk indicators and providing minority communities with access to healthcare promotion tools.

In addition, attempts to address hypertension diseases have been launched as part of the management strategy. Sreedhara et al. (2020) investigated their prior experiences with self-measured blood pressure measurement as well as telemedicine in the context of the treatment of hypertension. The reader is encouraged to draw from these experiences in order to improve the hypertension treatment strategies and activities that they currently employ. In the midst of the COVID-19 pandemic, Abbas et al. (2022) conducted qualitative interviews with postpartum women who had hypertensive conditions during pregnancy. These women had been infected with the virus. This study explains why it is essential to improve both the consistency and the content of therapy in order to raise the percentage of postpartum women who engage in preventive behaviors that lower their risk of developing cardiovascular disease.

Collaboration innovations are advantageous for preventing, managing, and controlling cardiovascular disease and risk factors. During the COVID-19 pandemic, numerous medical professionals and health healthcare settings were able to expedite innovation and adjust services in order to sustain hypertension management among their high-risk clients, as recounted by Abbas et al. (2022). Hence, they were able to influence future coordinated hypertension management efforts both before and after the public health crisis. In addition, public health personnel must be revitalized and transformed in order to prevent and manage noncommunicable illnesses. This is accomplished via the unique Field Epidemiology Training Program in illnesses, which strengthens workforce competence in CVD epidemiology, monitoring, and assessment to support CVD control policies and initiatives. For instance, resident programs in India collaborate with local partners to examine the prevalence of hypertension and possible treatments for the condition (Ramalingam et al., 2022). These types of community-based interventions may help in the process of improving the environmental and socioeconomic circumstances of communities that have traditionally been disadvantaged and are impacted by cardiovascular diseases.

Critique of Epidemiological Research Studies on CVD

Despite the fact that epidemiology has made major contributions to the knowledge of cardiovascular diseases as well as the policy response to these diseases, there are various criticisms that may be made about this field. Concerns about the possibility of confounding variables and bias in observational studies are often raised in evaluations of epidemiological research on cardiovascular diseases (CVD). Although randomization is often seen as being better than observational designs, current randomized controlled trials (RCTs) of cardiovascular outcomes in obstructive sleep apnea (OSA) have indicated that there is frequently a large amount of bias in RCTs (Pack et al., 2020). Even if a randomized controlled trial (RCT) is carried out properly, it is still possible that the resulting estimation of the treatment impact would be skewed. Nevertheless, if the estimate is generated from the incorrect target group, it is not very informative.

Research needs to be carried out on patients from the real world. In addition, randomized controlled trials may bring about a balance in expectations; nevertheless, when used in small numbers, these tests often reveal residual discrepancies in baseline covariates. Propensity score designs are aimed to directly offset the selection bias that is inherent in randomized trials. This is accomplished by researching patients from the real world, including those who excessively sleep, and by carefully constructing a sample with balanced variables (Pack et al., 2020). As a result, propensity score designs may yield more relevant and less biased results than RCTs in many instances. If one acknowledges that randomizing these patients to no therapy over an extended length of time is unethical, then alternate randomization methods are necessary. Even if regarded as ethical, there remains the practical obstacle that symptomatic patients or their providers would reject participation in studies in which clients will be left untreated for an extended period (Pack et al., 2020). Techniques such as the propensity score are advantageous in this case to eliminate bias and produce causal predictions from observational data.

The validity of causative estimates derived from a propensity score design is contingent on the assumption that there are no unobserved confounding variables. The reliability of this claim is increased if the covariate list is extensive and multidimensional, as this increases the likelihood that unobserved covariates are partly connected with and indirectly accounted for by the collection of observable covariates. It is also possible to do sensitivity studies to establish the degree of relationships between a hypothetical unobserved covariate and the exposures and outcomes of concern that would be necessary to negate the observed therapy outcomes (Pack et al., 2020). If these magnitudes are relatively big, then the observational researchs findings are robust with respect to unobserved variables. Conversely, if only modest connections may reverse the outcomes, then propensity score designs do not provide strong results. Regular reporting of relevant sensitivity assessments has the potential to boost the scientific validity of the findings from observational research using this methodology.

Conclusion

Epidemiological research has made a substantial contribution to the knowledge and policy approach to cardiovascular disease (CVD). Epidemiology studies have assisted in uncovering the risk factors that lead to the onset of cardiovascular disease, such as hypertension, hyperlipidemia, overweight, cigarette smoking, and poor diet. This study has also assisted in establishing the connections between these indicators associated and the onset of particular CVD, including stroke, heart attack, and hypertension. The establishment of policies and measures to prevent and manage CVD has been influenced by epidemiological studies. This contains suggestions for modifying ones lifestyle, like incorporating more physical activity and improving diet.

Epidemiology techniques such as dietary and social epidemiology have assisted in identifying risk factors for CVD and influencing preventative efforts. Many significant CVD risk factors have been discovered by epidemiological research, and policy reactions have included programs to encourage healthy lifestyles and avoid CVD. Epidemiology studies are susceptible to biases, which is an inaccuracy in a study design, execution, or analysis that might affect the findings. Critiques of epidemiological studies and policy measures stress the need for further study to comprehend the intricate relationships between obstructive sleep apnea and cardiovascular events, as well as the need for additional action to confront the magnitude of the issue. Community involvement and participation are required at all phases in order to design initiatives that offer vulnerable groups available, relevant, and affordable resources. Eventually, these effective multilevel initiatives directly affect CVD results and health equality, including reducing health inequalities, improving health habits and access, and diminishing the physiological impact of unfavorable circumstances.

Reference List

Abbas, A. et al. (2022) Commitment to hypertension control during the COVID-19 pandemic: million hearts initiative exemplars, Preventing Chronic Disease, 19. Web.

Al-Shamsi, S., Regmi, D. and Govender, R.D. (2019) Incidence of cardiovascular disease and its associated risk factors in at-risk men and women in the United Arab Emirates: a 9-year retrospective cohort study, BMC Cardiovascular Disorders, 19(1). Web.

Bu, F., Zaninotto, P. and Fancourt, D. (2020) Longitudinal associations between loneliness, social isolation and cardiovascular events, Heart, 106(18), pp.13941399. Web.

Casas, R. et al. (2018) Nutrition and Cardiovascular Health, International Journal of Molecular Sciences, 19(12), p.3988. Web.

Centers for Disease Control and Prevention. (2023) What is Epidemiology? | Teacher Roadmap. [online] Web.

Deng, L., Leng, B. and Nie, X. (2022) The cannabis paradox: contrasting role for marijuana in cardiovascular disease, Signal Transduction and Targeted Therapy, 7(1). Web.

Hinton, W. et al. (2018) Incidence and prevalence of cardiovascular disease in English primary care: a cross-sectional and follow-up study of the Royal College of General Practitioners (RCGP) Research and Surveillance Centre (RSC), BMJ Open, 8(8), p.e020282. Web.

Jordan, J. et al. (2020) Peer reviewed: CDCs sodium reduction in communities program: evaluating differential effects in food service settings, 20132016, Preventing Chronic Disease, 17. Web.

Long, C.R. et al. (2021) Reducing sodium intake in community meals programs: evaluation of the sodium reduction in communities program, Arkansas, 20162019, Preventing Chronic Disease, 18. Web.

Powell-Wiley, T.M. et al. (2022) Social Determinants of Cardiovascular Disease, Circulation Research, 130(5), pp.782799. Web.

Ramalingam, A. et al. (2022) Building noncommunicable disease workforce capacity through field epidemiology training programs: experience from India, 20182021, Preventing Chronic Disease, 19. Web.

Sreedhara, M. et al. (2022) Rapid evaluations of telehealth strategies to address hypertension: a mixed-methods exploration at two us health systems during the COVID-19 Pandemic, Preventing Chronic Disease,19. Web.

World Health Organization (2021) cardiovascular diseases (CVDs). [online] Who.int. Web.

Yin, T. et al. (2022) The association between dietary antioxidant micronutrients and cardiovascular disease in adults in the United States: a Cross-Sectional Study, Frontiers in Nutrition, 8. Web.

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