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Introduction
There are two categories of theories on ageing namely the damage based theory which explains that aging may be caused by low metabolism or inefficient immune system that occurs over a long period of time. The programmed theory suggests that tough environmental factors may lead to aging and death with the main cause of aging in this theory, genes, determine the lifespan of a mammalian (Frick, 2012). The human being aging is associated with the cellular, molecular and physiological changes of the body, which are characterized by deteriorating homeostatic balance associated with the increasing of neoplasia and other associated diseases (Becker et al., 2009). Aging is associated with the increase of telomere attrition, DNA mutation, and changes in pattern of methylation at the molecular level, which may interfere with the normal function involved in maintenance of genomic integrity, proteins in cellular growth, responses to cellular stress and inflammation according to Dr Sige Zou Phd. In Investigator Functional Geometric Unit research, Gaillard and Hua (2009) describe aging as a biological process that occurs in eukaryotic organisms. Genetic analyses have discovered that mutation in genes can affect the lifespan of an organism (Rubin & Babbie, 2010).
Research Questions
In investigating the molecular basis of aging we consider how genes determine the lifespan of a mammalian theory on gene support the fact that people with parents who lived long are likely to live long together with their generations, The molecular and physiological changes in the body and the role of DNA in the molecular level of aging. The study will investigate how knowledge can help in prevention of related diseases in aging? (Peters, et al. 2012).
The Aim of Research
The aim of this investigation of aging at molecular level is to investigate whether the research done may also investigate gerontology, the study of the aging process in the aspect of longevity, aging and death. Therefore, research on molecular virology in brief will be examined and entail the molecular basis of viral interaction with their hosts (Zglinicki, 2003). The investigation will also center on the genetic theory telomeres, research on DNA (deoxyribonucleic acid) replication in microorganisms and repair of mammalian cells when exposed to damaging agents of DNA signals transduction and Gene regulation, which will basically focus on transcriptional responses and signaling of cells in relation to their environment and to microbial pathogens (StachoD, et al., 2010). The focus will be on Research done by the Department on Microbiology and Molecular Genetics in the University of Pittsburgh shows that due to cellular senescence process, most cells cannot divide indefinitely (Kenyon, 2012).
Methodologies
The methods to be used in the research will include both qualitative and quantitative approaches where experiments could also be used to establish the process of aging with regards to involvement of cells (Salkind, 2009).
Expected Outcome
In conclusion, biogerontology aging is mostly concerned with genes, and studies are more focused on biology, chemistry, genetic life extension or anti aging treatments (Wisdom, Cavaleri, Onwuegbuzie & Green, 2012). Some biogerontologists argue that before we can cure aging, we must understand it fully, and due to the remedy of aging. In one of the studies conducted on projection of demographics, it was established that people who maintain a healthy lifestyle usually increase their lifespan as compared to those who do not (Fu, Csanaky & Klaassen, 2012).
References
Becker, M., Kleinsmith, L. J., Hardin, J. & Bertoni, G. P. (2009). The World of the Cell. 7 ed. San Francisco, CA: Pearson Benjamin Cummings.
Frick, M. (2012). Building a better hormone therapy? How understanding the rapid effects of sex steroid hormones could lead to new therapeutics for age-related memory decline. Behavioral Neuroscience, 126(1), 29-53.
Fu, Z. D., Csanaky, L., & Klaassen, D. (2012). Gender-divergent profile of bile acid homeostasis during aging of mice. PloS One, 7(3), 504-512.
Gaillard, E. & Hua, F. (2009). Aging in the human lens: molecular level studies of possible mechanisms of damage. Illinois: Northern Illinois University
Kenyon, M. (2012). Healthy Aging in the 22nd Century. Futurist, 46(5), 40-43.
Peters, L. et al. (2012). Lead concentrations in relation to multiple biomarkers of cardiovascular disease: the normative aging study. Environmental Health Perspectives, 120(3), 361-366
Rubin, A. & Babbie, E. (2010). Research methods for social work. New York, NY: Cengage Learning.
Salkind, N. (2009). Exploring research. Upper Saddle River, NJ: Prentice Hall.
StachoD, A., Burdukiewicz, A., Pietraszewska, J., Andrzejewska, J. & Chromik, K. (2010). Biological symptoms of aging in women regarding physical activity and lifestyle. Human Movement, 11(2), 172-178.
Wisdom, P., Cavaleri, A., Onwuegbuzie, J. & Green, A. (2012). Methodological reporting in qualitative, quantitative, and mixed methods health services research articles. Health Services Research, 47(2), 721-745
Zglinicki, T. (2003). Aging at the molecular level. New York, NY: Springer.
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