1. What are the pathophysiologic mechanisms of the disorder that you selected? W

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1. What are the pathophysiologic mechanisms of the disorder that you selected? W

1. What are the pathophysiologic mechanisms of the disorder that you selected? Which of
the I’s (Inflammation, Infection, Immunity, Injury/Proliferation) is/are linked to this
disorder? Minimum two. Please include complications if relevant.
2. Describe the clinical features of this disorder and relevant diagnostic tests.
3. Describe how the pathophysiology of the disorder you selected is impacted by genetic,
demographic, cultural, gender, race or ethnic variables.
All 4I’s papers should include a minimum of five resources:
Please do not use websites for references unless you are gathering statistics, demographic data,
or national guidelines.
1) McCance pathophysiology text
2) A text selected from Access Medicine search engine available on UM-Flint library resources
under the alpha index. This text may assist you in providing an overview of your topic,
describing the disease and pathophysiology, and associated complications related to the 4I’s.
3) and 4) A minimum of two Level I-VI references. The following guidelines are to be used:
o Level I: Evidence from a systematic review or meta-analysis of all relevant randomized
controlled trials (RCTs), or evidence-based clinical practice guidelines based on systematic
reviews of RCTs
o Level II: Evidence obtained from at least one well-designed RCT
o Level III: Evidence obtained from well-designed trial without randomization
o Level IV: Evidence from well-designed case-control and cohort studies
o Level V: Evidence from systematic reviews of descriiptive and qualitative studies
o Level VI: Evidence from a single descriiptive or qualitative study
o Level VII: Evidence from the opinion of authorities and/or reports of expert committees.
From Melnyk, B.M., & Fineout-Overholt, E. (2019) Evidence based practice in nursing
&healthcare. A guide to best practices. Philadelphia: Lippincott Williams & Wilkins.
5) A minimum of one review article within the last five years (Level VII).
The references must be as current as possible. The evidenced based research reference
should be published within the last five to ten years. A more recent reference would be
preferable if available as research for many of these topics is evolving rapidly. Older references
may be used if seminal.

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